View abstract. First-aid measures Inhalation Move to fresh air. Planta Med 2002;68(2):128-132. Ha, K. T., Kim, J. K., Kang, S. K., Kim, D. W., Lee, Y. C., Kim, H. M., and Kim, C. H. Inhibitory effect of Sihoga-Yonggol-Moryo-Tang on matrix metalloproteinase-2 and -9 activities and invasiveness potential of hepatocellular carcinoma. Cheng, K. T., Huang, Y. C., Lin, Y. S., Su, B., and Chen, C. M. Effects of baicalin on the gene expression of surfactant protein A (SP-A) in lung adenocarcinoma cell line H441. WebAbstract This study was carried out to investigate the antifibrotic effects of methanol extracts from the traditional Chinese medicinal herb, the root of Scutellaria baicalensis Georgi, on liver fibrosis induced by bile duct ligation and scission Altavilla D, Squadrito F, Bitto A, et al. Chalasani N, Vuppalanchi R, Navarro V, et al. It can cause drowsiness, fever, lung inflammation, and other information Some constituents may also have neuroprotective (4) (5) , anticonvulsant (6) , and anti-inflammatory (17) effects. Fitoterapia 2009;80(7):448-452. Antiplatelet, anticoagulant, and profibrinolytic activities of baicalin. WebChinese skullcap, Scutellaria Baicalensis, also known as (Baikal) Baical Skullcap, is a herb that belongs to the Lamiaceae mint family. Memorial Sloan Kettering Cancer Center makes no warranties nor express or implied representations whatsoever regarding the accuracy, completeness, timeliness, comparative or controversial nature, or usefulness of any information contained or referenced on this Web site. Pasanen MK, Fredrikson H, Neuvonen PJ, Niemi M. Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin. 2003;34(3):504-506. Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others. B., Blach-Olszewska, Z., and Aliev, G. Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? Zhongguo Zhong.Yao Za Zhi 2001;26(11):768-769. The dose of your metformin (Glucophage) might need to be changed. Protective effect of scutellaria baicalensis stem-leaf total flavonoid against hippocampus neurodamage induced by injection A25-35. Huang, R. L., Chen, C. C., Huang, H. L., Chang, C. G., Chen, C. F., Chang, C., and Hsieh, M. T. Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis. However, both S. baicalensis root and its main flavonoid baicalin appear to have dose-dependent pro- and anti-angiogenic effects . Another Scutellaria Baicalensis Root Extract trade name mixture (90% ethanol and butylene glycol extract) Takeshita K, Saisho Y, Kitamura K, et al. View abstract. Nahrung 2004;48(2):123-128. Razina, T. G., Udintsev, S. N., Tiutrin, I. I., Borovskaia, T. G., and Iaremenko, K. V. [The role of thrombocyte aggregation function in the mechanism of the antimetastatic action of an extract of Baikal skullcap]. Cell Mol Biol Res 1993;39(2):119-124. Ann Palliat Med. Therefore, if you are a diabetic patient, you should stay away from such herbs. View abstract. Cao, H., Jiang, Y., Chen, J., Zhang, H., Huang, W., Li, L., and Zhang, W. Arsenic accumulation in Scutellaria baicalensis Georgi and its effects on plant growth and pharmaceutical components. Talk with your healthcare provider before using this product if you are taking lithium. Baikal skullcap might affect the thyroid and may affect how antithyroid medications work. View abstract. Yoo, H. H., Park, J. H., and Kwon, S. W. In vitro cytotoxic activity of some Korean medicinal plants on human cancer cell lines: enhancement in cytotoxicity by heat processing. View abstract. [The Baikal scullcap (Scutellaria baicalensis Georgi)--a potential source of new drugs]. 2008;31(5):707-710. S. barbata flavonoids have produced synergistic effects in combination with cisplatin in ovarian cancer cells(32). Am J Chin Med 2011;39(4):693-704. Am J Chin Med 2001;29(1):69-81. Baikal skullcap might decrease how quickly the liver breaks down some medications. Jianjun, J. and Huiru, D. Preparation of high-purity baicalein from Scutellaria baicalensis Georgi. Planta Med 2000;66:70-1. It often is used in combination with other botanicals such as PC-SPES and sho-saiko-to. Cheng, K. T., Hou, W. C., Huang, Y. C., and Wang, L. F. Baicalin induces differential expression of cytochrome C oxidase in human lung H441 cell. In using this website you agree that neither Memorial Sloan Kettering nor any other party is or will be liable or otherwise responsible for any decision made or any action taken or any action not taken due to your use of any information presented at this website. The appropriate dose of Baikal skullcap depends on several factors such as the user's age, health, and several other conditions. Gao Z, Huang K, Yang X, Xu H. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Bensky D, Gamble A, Kaptchuk T. Chinese Herbal Medicine Materia Medica. Huang, R. L., Chen, C. C., Huang, H. L., Chang, C. G., Chen, C. F., Chang, C., and Hsieh, M. T. Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis. Nishioka T, Kawabata J, Aoyama Y. Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis. Monday through Friday, 8 a.m. to 6 p.m. (Eastern time), Monday through Friday, 9 a.m. to 5 p.m. (Eastern time), Monday to Friday, 8 a.m. to 6 p.m. (Eastern time). Int Immunopharmacol. A traditional Chinese herbal medicine loaded with potent antioxidant and anti-inflammatoryflavonoids such as baicalin, baicalein, and wogonin. If combined with such drugs, it can have potential side effects, as resulted in a laboratory test. Huang, S. T., Wang, C. Y., Yang, R. C., Chu, C. J., Wu, H. T., and Pang, J. H. Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells. The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokines. View abstract. Copyright 2023 by RxList Inc. An Internet Brands company. View abstract. J Nat Prod 1998;61:1413-5. View abstract. Baikal Scullcap, Baikal Skullcap Root, Chinese Skullcap, Escutelaria Asiatica, Huang Qin, Huangquin, Hwanggum, Ogon, Ou-gon, Racine de Scutellaire du Lac Bakal, Radix Scutellariae, Scullcap, Scute, Scutellaire, Scutellaire Chinoise, Scutellaire du Lac Bakal, Scutellaria, Scutellaria baicalensis, Scutellaria macrantha, Scutellariae Radix, Skullcap, Wogon. This will help them manage your care and keep you safe. How It Works Purported Uses and Benefits Do Not Take If Side Effects Special Point Back to top For Healthcare Professionals Scientific Name Clinical Summary Purported Uses and Benefits Mechanism of Action Contraindications Adverse Reactions References Back to top # A B Baikal skullcap is also sometimes applied to the skin for psoriasis. View abstract. Mol Urol. Nutr Res 2009;29:298-304. Am J Chin Med 2009;37(3):621-623. 1989;35(3):331-335. Bochorakova, H., Paulova, H., Slanina, J., Musil, P., and Taborska, E. Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties. In Vivo 2004;18(4):497-503. A Scutellaria Baicalensis Root Extract trade name mixture (30% ethanol extract) is reported to contain flavonoid compounds. Morgan SL, Baggott JE, Moreland L, et al. Baicalein protects against doxorubicin-induced cardiotoxicity by attenuation of mitochondrial oxidant injury and JNK activation. [Clinical and experimental study on inhibitory effect of sanhuang mixture on platelet aggregation]. Nutr Res 2009;29:298-304. View abstract. We currently have no information for BAIKAL SKULLCAP overview. Anticonvulsant effect of wogonin isolated from. Side Effects Baikal skullcap is POSSIBLY SAFE for most adults when taken by mouth. Phytomedicine. Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root. Monday through Friday, 8 a.m. to 6 p.m. (Eastern time), Monday through Friday, 9 a.m. to 5 p.m. (Eastern time), Monday to Friday, 8 a.m. to 6 p.m. (Eastern time). Chang, Y. L., Shen, J. J., Wung, B. S., Cheng, J. J., and Wang, D. L. Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. Supplementing with skullcap may provide several health benefits, such as improved mood, reduced inflammation, and anticancer effects. Shih, H. C., Hsu, C. S., and Yang, L. L. In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root. 5-17-2011;135(2):359-368. View abstract. WebSide Effects Precautions Interactions Dosing Reviews (4) Overview Baikal skullcap (Scutellaria baicalensis) is a plant native to China and Korea. J Med Chem 10-21-2004;47(22):5555-5566. View abstract. Neurosci Lett. Kimura, Y., Matsushita, N., and Okuda, H. Effects of baicalein isolated from Scutellaria baicalensis on interleukin 1 beta- and tumor necrosis factor alpha-induced adhesion molecule expression in cultured human umbilical vein endothelial cells. Eksp Klin Farmakol 1997;60:49-51. Larger studies in humans that test safety and effectiveness are needed to determine under what circumstances S. baicalensis may be beneficial. There could be several possible side effects of Scutellaria baicalensis if taken by mouth. Before taking Baikal skullcap, talk to your healthcare provider if you take any medications that are changed by the liver. The active ingredient in Baikal skullcap, baicalin, is used in combination with shung hua (ephedra) to treat upper respiratory tract infections. View abstract. View abstract. Pharmacogenomics of human OATP transporters. Kimura, Y., Yokoi, K., Matsushita, N., and Okuda, H. Effects of flavonoids isolated from scutellariae radix on the production of tissue-type plasminogen activator and plasminogen activator inhibitor-1 induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells. Li, T., Li, N., Guo, Q., Ji, H., Zhao, D., Xie, S., Li, X., Qiu, Z., Han, D., Chen, X., and You, Q. Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. J Ethnopharmacol. Vopr.Onkol. J Ethnopharmacol. This could increase how much lithium is in the body and result in serious side effects. Some constituents may also have neuroprotective(4)(5), anticonvulsant(6), and anti-inflammatory(17) effects. View abstract. Martin, J. and Dusek, J. Flavonoid accumulation in Scutellaria baicalensis Georgii in vitro cultures upon treatment with sodium cinnamate. Biochem Biophys Res Commun 9-24-2000;276(2):534-538. 2007;60(5-6):294-297. Memorial Sloan Kettering was founded in 1884, and today is a world leader in patient care, research, and educational programs. Woo, K. J., Lim, J. H., Suh, S. I., Kwon, Y. K., Shin, S. W., Kim, S. C., Choi, Y. H., Park, J. W., and Kwon, T. K. Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBPbeta DNA-binding activity. [Effects of Honeysuckle flower and Scutellaria Baicalensis Georgi on constraction and electric activity of rabbit small intestine smooth muscle]. Zhu, G., Li, C., and Cao, Z. Inhibitory effect of flavonoid baicalin on degranulation of human polymorphonuclear leukocytes induced by interleukin-8: potential role in periodontal diseases. Huang, S. T., Wang, C. Y., Yang, R. C., Chu, C. J., Wu, H. T., and Pang, J. H. Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells. Wu, J., Hu, D., and Wang, K. X. WebSkullcap (Scutellaria lateriflora ) is a plant native to the US and Europe. View abstract. Avoid skin and eye contact and breathing in dust. The compound baicalein exhibited only inhibitory effects(9). Vestn.Ross.Akad.Med Nauk 1995;(1):29-38. Skin contact Rinse skin with water/shower. Planta Med 2006;72(14):1318-1321. View abstract. J Ethnopharmacol. Kim, B. R., Kim, D. H., Park, R., Kwon, K. B., Ryu, D. G., Kim, Y. C., Kim, N. Y., Jeong, S., Kang, B. K., and Kim, K. S. Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes. Suppose you are taking any particular hormone synthesis medicine. A number of constituents including flavonoids are thought to be responsible for these activities. J Ethnopharmacol. Cancer Lett. Immunopharmacology 2000;49:295-306. Mu, R., Qi, Q., Gu, H., Wang, J., Yang, Y., Rong, J., Liu, W., Lu, N., You, Q., and Guo, Q. Get medical attention if irritation develops and persists. View abstract. View abstract. Ready to start planning your care? [Study on the inhibitory activity, in vitro, of baicalein and baicalin against skin fungi and bacteria]. View abstract. Seattle, WA: Eastland Press 1996:107-8. Lin, C. C., Kuo, C. L., Lee, M. H., Lai, K. C., Lin, J. P., Yang, J. S., Yu, C. S., Lu, C. C., Chiang, J. H., Chueh, F. S., and Chung, J. G. Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. Levy RM, Khokhlov A, Kopenkin S, et al. Flavocoxid, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, blunts pro-inflammatory phenotype activation in endotoxin-stimulated macrophages. Bioorg.Med Chem 8-1-2008;16(15):7516-7524. Razina, T. G., Udintsev, S. N., Tiutrin, I. I., Borovskaia, T. G., and Iaremenko, K. V. [The role of thrombocyte aggregation function in the mechanism of the antimetastatic action of an extract of Baikal skullcap]. Gao, J., Morgan, W. A., Sanchez-Medina, A., and Corcoran, O. Our scientists pursue every aspect of cancer researchfrom exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. The purpose of this study was to investigate whether SB exhibited anticancer activity in EGFR TKI-resistant lung cancer cells and to explore the underlying mechanism. A large long-term population study identifies S. barbata among the single herbs used in TCM that may reduce risk of hepatocellular carcinoma in hepatitis B patients(9). Che, Q. M., Huang, X. L., Li, Y. M., Kun, Z., Teruaki, A., and Masao, H. [Studies on metabolites of baicalin in human urine]. Altern.Ther.Health Med. 2-1-2010;84(2):137-144. Vopr.Onkol. J Med Food 2007;10:442-51. Phytother.Res 2007;21(9):900-903. Side effects are few and may include drowsiness. J Nat Prod 1997;60(6):598-601. Zhang, S., Jin, Y., Zhu, W., Tang, J., Hu, S., Zhou, T., and Chen, X. Baicalin released from Scutellaria baicalensis induces autotoxicity and promotes soilborn pathogens. Activation in endotoxin-stimulated macrophages electric activity of rabbit small intestine smooth muscle.! No information for Baikal skullcap, talk to your healthcare provider if you take any medications that changed... On the pharmacokinetics of atorvastatin and rosuvastatin dual inhibitor of cyclooxygenase and 5-lipoxygenase, blunts pro-inflammatory activation! Flavonoid accumulation in Scutellaria baicalensis Georgi on constraction and scutellaria baicalensis root extract side effects activity of rabbit small smooth! Flavonoids are thought to be changed rabbit small intestine smooth muscle ] Zhong.Yao Za 2001. G. 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