J Thromb Haemost. (PubMed), 27.
Researchers say the compound could be used to treat diabetes and its complications in the future, but more research is needed. 2009;84(1):1-10. Vaz-da-Silva M, Loureiro AI, Falcao A, et al.
Research most supports its use for cardiovascular protection and blood pressure regulation. (PubMed), 72. (PubMed), 57. Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals. Glaser JH. Am J Epidemiol.
Brown, V. A., Patel, K. R., Viskaduraki, M., Crowell, J.
(PubMed), 17. Vingtdeux V, Giliberto L, Zhao H, et al. Most resveratrol supplements available in the US contain extracts of the root of Polygonum cuspidatum, also known as Fallopia japonica, Japanese knotweed, or Hu Zhang (150).
Yurdagul A, Jr., Kleinedler JJ, McInnis MC, et al. Initial studies of the pharmacokinetics of trans-resveratrol in humans found only traces of the unmetabolized resveratrol in the plasma upon oral exposure of single trans-resveratrol doses of 5 to 25 mg. It is fat-soluble and possesses anticarcinogenic, antioxidant, and estrogenic activity. No changes were found in measures of diastolic blood pressure, total cholesterol, triglycerides, and markers of liver function (131).
resveratrol (PubMed), 19. 1998;68(6):1208-1214. A 2016 study fed mice a high-protein, high-polyunsaturated fat diet and also gave them resveratrol supplements. Lin MT, Yen ML, Lin CY, Kuo ML.
2001;161(15):1844-1848.
A few of these health benefits include: Research shows that resveratrol plays a role in protecting ovarian health, and in relieving poor pulmonary function. (PubMed), 58. 2007;79(1):17-26. 
By inhibiting COX enzymes that cause inflammation on a cellular level, resveratrol should theoretically help with conditions such as osteoarthritis. Yet, in an unrandomized and unblinded trial in patients with multiple myeloma, the administration of SRT501 was associated with a number of serious adverse effects, including kidney failure, such that the trial was halted (77). Moreover, unlike normal cells, cancer cells proliferate rapidly and are unable to respond to cell death signals that initiate apoptosis. Resveratrol is a powerful antioxidant that provides protective benefits for your heart, brain and body. Many people use resveratrol as a health-boosting supplement. Baur JA, Pearson KJ, Price NL, et al. Klinge CM, Blankenship KA, Risinger KE, et al. Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamics. Fujitaka K, Otani H, Jo F, et al.
Resveratrol counteracted oxidative stress and -amyloid peptide-induced toxicity in cultured neuroblastoma (64).
Cell-cycle dysregulation and anticancer therapy.
Supplements arent regulated by the U.S. Food and Drug Administration (FDA), so you can never be certain you are getting the amount of resveratrol that a product claims it provides. Following DNA damage, the cell cycle can be transiently arrested to allow for DNA repair or activation of pathways leading to cell death (apoptosis) if the damage is irreparable (29).
(PubMed), 126. 2014;19(11):17578-17603. Neuroprotective effects of resveratrol against intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats.
Sengottuvelan M, Nalini N. Dietary supplementation of resveratrol suppresses colonic tumour incidence in 1,2-dimethylhydrazine-treated rats by modulating biotransforming enzymes and aberrant crypt foci development. (PubMed), 111.
Here are a few more benefits resveratrol may have for people with diabetes (28): Resveratrol may even provide more benefits for people with diabetes than those who dont have it. Activity in vitro of resveratrol on granulocyte and monocyte adhesion to endothelium. Lin SJ, Defossez PA, Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. 2010;285(12):9100-9113. Resveratrol feeding also extended the lifespan of worms (Caenorhabditis elegans) and fruit flies (Drosophila melanogaster) by a similar mechanism (118). Resveratrol is a naturally-occurring compound present in grapes, some berries, and other fruits and nuts.
The best food sources of resveratrol are red grapes and red wine.
Cell Metab. 2003;993:276-286; discussion 287-278.
Lancet.
Br J Haematol.
Resistance against oxidative stress-related damage in primary neuronal cells treated with resveratrol has been associated with the induction of heme oxygenase-1 (HO-1), an enzyme that degrades pro-oxidant heme (65).
(PubMed), 97. Duffy SJ, Vita JA. trans-resveratrol content in commercial peanuts and peanut products. Resveratrol has been found to inhibit the expression of adhesion molecules in cultured endothelial cells (43, 44). Information about the bioavailability of resveratrol in humans is important because most of the experimental research conducted to date has been preclinical, i.e., in vitro, exposing cells to resveratrol concentrations up to 100 times greater than peak plasma concentrations observed in humans, and in animal models given very high (non dietary) doses of resveratrol (13). Cartilage breakdown can cause joint pain and is one of the main symptoms of arthritis (33). Dietary resveratrol does not affect intestinal tumorigenesis in Apc(Min/+) mice. (PubMed), 138. Resveratrol May Be Beneficial for People with Diabetes, 13 Emerging Benefits and Uses of Yuzu Fruit, Weaker Grip Strength May Be a Sign of Dementia, Redefining Healthy Online and At The Clinic: 6 Dietitians Who 'Get It', ButcherBox Review 2022: A Dietitians Expert Take, Nope, Gyros and Shawarmas Aren't The Same. Here are 13 emerging benefits and uses of yuzu fruit. 1999;47(4):1533-1536. (PubMed), 119.
Cytochrome P450 induction properties of food and herbal-derived compounds using a novel multiplex RT-qPCR in vitro assay, a drug-food interaction prediction tool. Current data suggest that resveratrol could improve specific metabolic variables in individuals with type 2 diabetes (138, 139), but more research is needed to assess its effect in individuals at risk for diabetes, including obese subjects with impaired glucose tolerance. 2007;21(2):365-370. Biochem Biophys Res Commun. (2013). Haider UG, Sorescu D, Griendling KK, Vollmar AM, Dirsch VM.
Goldberg DM, Yan J, Soleas GJ. 2012;17(3):437-448. A diet high in antioxidant-rich foods promotes high levels of HDL (good cholesterol) and low levels of LDL (bad cholesterol). Brito P, Almeida LM, Dinis TC. Learn more about the health benefits of red wine here. However, in cell culture experiments, resveratrol was found to act either as an estrogen agonist or as an estrogen antagonist depending on such factors as cell type, estrogen receptor isoform (ER or ER), and the presence of endogenous estrogens (23). Siemann EH, Creasey LL. J Biol Chem. McCann SE, Sempos C, Freudenheim JL, et al. (PubMed), 11. The estrogen hormone can aggravate estrogen-dependent tumors in prostate and breast cancers. However, at doses of 2.5 grams (g) or more per day, the following side effects may occur: Researchers conducting long-term clinical trials did not record any major side effects. (PubMed), 99. (PubMed), 80. Shen MY, Hsiao G, Liu CL, et al.
Resveratrol treatment as an adjunct to pharmacological management in type 2 diabetes mellitus-systematic review and meta-analysis. LDL oxidation contributes to plaque buildup in artery walls (9, 14). 1995;17(1):1-3. Resveratrol is a powerful antioxidant with great potential. Research has linked the compound to potential health benefits such as improved brain health and blood pressure. 2003;64(5):1029-1036. While cells that line the digestive tract are exposed to unmetabolized resveratrol, other tissues are likely exposed to resveratrol metabolites.
Despite the many proposed health benefits of resveratrol, there are some negative effects with this compound, especially for those using certain drugs. 2004-2022 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company.
Am J Clin Nutr. (PubMed), 106. Arthritis is a common affliction that leads to joint pain and loss of mobility (33). (PubMed), 30. Chen ZH, Hurh YJ, Na HK, et al. Resveratrol has been found to inhibit the proliferation of VSMCs in culture (45-47), as well as in vivo (48). Researchers are investigating if resveratrol can help prevent or treat numerous conditions, including heart disease, cancer, and dementia. Drug Metab Rev. Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults.
1993;341(8852):1103-1104. Wilson T, Knight TJ, Beitz DC, Lewis DS, Engen RL. Skincare and cosmetic companies are increasingly using resveratrol as an ingredient in their products. Frankel EN, Waterhouse AL, Kinsella JE. Curr Pharm Des. 2014;34(23):7862-7870.
J Biol Chem. Renaud S, de Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Zhuang H, Kim YS, Koehler RC, Dore S. Potential mechanism by which resveratrol, a red wine constituent, protects neurons.
It is present in more than 70 plant species, primarily in the skin and seeds of red grapes.
Resveratrol in primary and secondary prevention of cardiovascular disease: a dietary and clinical perspective. Vitaglione P, Sforza S, Galaverna G, et al. 2002;50(11):3337-3340. FASEB J. resveratrol quercetin
Scientists have discovered several healthy chemicals in red wine that may offer health benefits. Cardiovasc Drug Rev. (PubMed), 77. Mol Pharmacol. Capiralla H, Vingtdeux V, Zhao H, et al.
Arch Intern Med. In fact, resveratrol has been shown to influence gene expression to turn on factors that code for longevity in cells. Mutat Res. The interaction of resveratrol with ferrylmyoglobin and peroxynitrite; protection against LDL oxidation. Inflammation and atherosclerosis: a review of the role of interleukin-6 in the development of atherosclerosis and the potential for targeted drug therapy.
However, the authors of that study say more research is needed before specific recommendations can be made about the best dose of resveratrol to maximize blood pressure benefits. 2007;12:4839-4854. Resveratrol was also found to extend the lifespan of mice on a high-calorie diet such that their lifespan was similar to that of mice fed a standard diet (120). 2011;4(9):1419-1425.
Resveratrol has a similar chemical structure to synthetic estrogen agonists. 2002;115(3):378-380.
2003;309(4):1017-1026. Albani D, Polito L, Batelli S, et al.
However, its not clear if they would have a similar effect in humans. Resveratrol administration has increased the lifespans of yeast, worms, fruit flies, fish, and mice fed a high-calorie diet, but it is not known whether resveratrol will have similar effects in humans.
Cancer Lett. Therefore, high intakes of resveratrol (i.e., from supplements) could potentially reduce the metabolic clearance of drugs that undergo extensive first-pass metabolism by CYP3A4, hence increasing the bioavailability and risk of toxicity of these drugs. Although resveratrol bioavailability to the brain is uncertain (78), a randomized, double-blind, placebo-controlled study has reported an increase in cerebral blood flow in the prefrontal cortex of healthy young subjects (ages, 18-29 years) following a single oral dose of 500 mg of resveratrol.
2006;96(1):145-153.
The proliferation of vascular smooth muscle cells (VSMCs) plays an important role in the progression of hypertension, atherosclerosis, and restenosis (when treated arteries become blocked again). Effect of trans-resveratrol on the thrombogenicity and atherogenicity in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice.
The articles on Health Guide are underpinned by peer-reviewed research and information drawn from medical societies and governmental agencies. 2010;70(19):7392-7399. A clinical study of 40 healthy volunteers evaluated the effect of resveratrol on IGF-1 levels.
Resveratrol (3,4',5-trihydroxystilbene) belongs to a class of polyphenolic compounds called stilbenes (1). The Linus Pauling Institute's Micronutrient Information Center provides scientific information on the health aspects of dietary factors and supplements, food, and beverages for the general public. (PubMed), 115. Centers for Disease Control and Prevention. (PubMed), 88. 2010;224(1):325-329. Although you can find it in peanuts, blueberries and cranberries, its most prominent in the skin of grapes and shines through in natural grape juice and red wine. The information on dietary factors and supplements, food, and beverages contained on this website does not cover all possible uses, actions, precautions, side effects, and interactions. When people consume reservatrol, it helps the body detoxify harmful molecules, much like antioxidants. Arterioscler Thromb Vasc Biol. Defective cell cycle regulation may result in the propagation of mutations that contribute to the development of cancer. 2005;12(6):596-600.
Therefore, because of variations between types of wine, vintages, and regions, it is very difficult to provide accurate estimates of resveratrol content in the thousands of wines from worldwide wineries. (PubMed), 123.
Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells. Zumpano says antioxidants help with multiple systems in your body. 2014;19(11):17154-17172. Resveratrol stimulates nitric oxide production by increasing estrogen receptor alpha-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells. They wrap around the cell like a nice layer, so when you have compounds floating around your bloodstream and the environment that are trying to attack and damage that cell, you have this extra layer of protection.. The results of epidemiological studies addressing this question have been inconsistent. Fremont L. Biological effects of resveratrol.
Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms.
Mol Nutr Food Res. Plants make resveratrol to help protect themselves from damage and infections (Salehi, 2018). Therefore, if you combine polyphenols and alcohol, you have an even greater blood-thinning effect. (PubMed), 68. These structural changes were associated with significant improvements in spatial learning, memory formation, and mood function (56).
Novel strategies for preventing diabetes and obesity complications with natural polyphenols. 2003;36(1):79-87.
Healthy people seem to tolerate them well (47). Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Here are just a few: Abnormal cholesterol levels are one of the most important risk factors for coronary heart diseasea condition that occurs when plaque builds up inside the arteries that supply blood to your heart. Tome-Carneiro J, Gonzalvez M, Larrosa M, et al. 2005;49(5):405-430. Resveratrol has been found to inhibit the proliferation of a variety of human cancer cell lines, including those from breast, prostate, stomach, colon, pancreatic, and thyroid cancers (2).
These tumors have many estrogen receptors, because they require the hormone to be able to grow. J Agric Food Chem. Additional evidence of the potential of resveratrol to mimic the metabolic benefits of caloric restriction on cognitive health may come from ongoing clinical trials in both healthy older individuals and AD patients (128). 2004;25(13):1153-1162. Alcohol can also act as a blood thinner, so red wine, when consumed responsibly, can help reduce clot formation. Klinge CM, Wickramasinghe NS, Ivanova MM, Dougherty SM. Larger and long-term studies will be needed to determine if resveratrol can prevent cancer (Brown, 2010). Oregon State University, Updated in May 2015 by:
A trial evaluating the safety of oral trans-resveratrol in 10 subjects found that a single dose of 5,000 mg resulted in no serious adverse effects (10). resveratrol softgels integrative therapeutics formula aging hp mg anti ultra
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